Among the new introductions is a 95% LTV range, with two-year fixes from 3.69% and five-year fixed rates at 4.55%.
85% and 90% LTV two-year fixed rates will also see reductions of up to 13bps.
Barclays is also enhancing its buy-to-let proposition, increasing the maximum loan size on all 75% LTV products to £1m and introducing a £250 cashback option to replace the free legal option on its Switch and Save package.
New buy-to-let rates include a 1.99% three-year fixed rate at 60% LTV and a 3.49% ten-year fixed rate up to 75% LTV.
Existing buy-to-let rates for purchase and remortgage will see rate cuts of up to 40bps.
In a statement, Barclays said: "As we move further into spring, we believe the new range will build on our strong proposition and provides a comprehensive range of products that will be attractive to both residential and buy-to-let investors."