New three-year fixed rates start from 2.45% up to 85% LTV, 2.65% up to 90% LTV and 3.60% up to 95% LTV.
The new deals also come with no product fee and a free standard property valuation.
Miguel Sard, head of mortgages at Santander, said: “With a zero product fee, free valuations and £1,000 cashback, first-time buyers with Santander now have extra money available to help get them on their way to turning their new home into their dream home.”